Sunday, January 15, 2012

Protection of the heart at a distance

ScienceDaily (Jan. 13, 2012) ? Novel avenues to treat a heart attack have been developed: in patients, who have a blood pressure cuff several times briefly inflated before they undergo coronary artery surgery with cardiopulmonary bypass, the heart is protected from damage.

This is the result of a clinical study recently reported by a group of scientists from the University Duisburg-Essen (UDE) in Circulation Research, the official journal of the American Heart Association.

A team of researchers from the Institute of Pathophysiology, the Clinic of Cardiothoracic Surgery and the Clinic of Anesthesiology, which was led by Professor Gerd Heusch, found such protection of the heart at a distance. They first identified STAT5 as a protective molecular signal in the human heart. STAT signals improve the function of mitochondria, i.e. the cellular powerplants, and reduce the size of a myocardial infarction in the experiment.

In a myocardial infarction, parts of the cardiac muscle receive no blood supply because the coronary vessels are occluded. Cardiovascular disease is the most frequent cause of death in Germany, and 70.000 people annually die from myocardial infarction in Germany. The basic and translational research of Prof. Heusch on protection of the heart from infarction is supported by the German Research Foundation.

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The above story is reprinted from materials provided by Universit?t Duisburg-Essen, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Gerd Heusch, Judith Musiolik, Eva Kottenberg, J?rgen Peters, Heinz Jakob, Matthias Thielmann. STAT5 Activation and Cardioprotection by Remote Ischemic Preconditioning in Humans. Circulation Research, November 23, 2011 DOI: 10.1161/%u200BCIRCRESAHA.111.259556

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/3FuE0Aao7XY/120113210355.htm

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Dark Faerie Roleplay (Full of Politics, Intrigue and Death)

This is an idea I have to first waggle under people's noses, because don't know much about Faeries, but I do know these are kinda beings who kidnap, murder and generally aren't whimsical at all. The plot got so far, is two families, the one in the power and the next in line, made a treaty to never disturb humans, after a great cataclysm. When the second family break treaty by kidnapping children from orphanages, to use as slave/spies civil war breaks out.

Need anymore, also would love for a Co GM in this, so thoughts, suggestions?

We help the multi-nationals
when they cry out protect us.
The locals scream and shout a bit,
but we don?t let that affect us.
We?re here to lend a helping hand
in case they don?t elect us.
How dare they buy our products
yet still they don?t respect us.

Billy Bragg - The Marching Song Of The Covert Battalions

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/mSZY4tMkNB8/viewtopic.php

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Saturday, January 14, 2012

Moscow police arrest 2 at protest (AP)

MOSCOW ? Russian police have detained two officials of a liberal opposition party after a protest rally in Moscow against election fraud.

The Saturday rally by the Yabloko party was sanctioned for 300 participants, but police counted about 350.

Organizer Maya Zavyalova was detained on charges with violating public order, the state news agency RIA-Novosti quoted a police spokesman as saying. The charge carries a fine of 2,000 rubles (about $60).

Yabloko's deputy chairman Sergei Mitrokhin was detained after entering the rally by skirting police security barriers. He was charged with disobeying police, RIA-Novosti said. That charge carries a potential sentence of 15 days in jail.

The rally protested alleged fraud in last December's parliamentary election and called for volunteers to monitor March's presidential vote.

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/ap/20120114/ap_on_re_eu/eu_russia_protest

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Penn State President Rodney Erickson Faces Harsh Alumni After Jerry Sandusky Scandal

KING OF PRUSSIA, Pa. -- A plan designed to soothe angry Penn State University alumni may instead be sowing seeds of outrage.

School President Rodney Erickson was scheduled to appear Thursday night at a hotel near Philadelphia at the second of three town hall events, and alumni weren't exactly rolling out the red carpet for him.

Former Penn State and pro football star Franco Harris scheduled a competing event at the King of Prussia hotel after broad dissatisfaction with Erickson's first talk in Pittsburgh on Wednesday. A third event is scheduled for Friday in New York.

But even some critics say Erickson shouldn't be getting all the blame for what many view as a floundering public relations effort.

He's trying to repair the school's image more than two months after the arrest of former assistant football coach Jerry Sandusky on sexual abuse charges brought controversy, criticism and contemplation to Happy Valley.

A 2002 alumnus, Ryan Bagwell, who's seeking a trustee seat in voting that will start next week, said Erickson "takes his marching orders from the Board of Trustees," which has "sent him out on this three-day spree."

"We want to hear from the trustees. We want them to explain why they made the decisions they did," Bagwell said. "Their silence is just incredible. It just keeps getting worse."

The chairman and vice chairman of the Board of Trustees released a statement Thursday evening responding to questions raised at the Pittsburgh meeting, including about the firing of legendary football coach Joe Paterno. Paterno, they said, was removed in November instead of being allowed to retire after the season because of "extraordinary circumstances."

"The details of his retirement are being worked out and will be made public when they are finalized," said the statement from Chairman Steve Garban and Vice Chairman John Surma. "Generally speaking, the University intends to honor the terms of his employment contract and is treating him financially as if he had retired at the end of the 2011 football season."

In Pittsburgh, the most passionate applause came after one questioner suggested that the entire board of trustees step down. Several others questioned why Penn State is still struggling to manage questions from the public and the media so many weeks after the crisis began.

"If you keep doing the same thing over and over again, you shouldn't expect different results," said Tim King, vice president of the greater Pittsburgh alumni chapter.

The alumni meetings come as investigators re-interview current and former employees of Penn State's athletic department as part of the case against the 67-year-old Sandusky, the former assistant coach who's charged with sexually abusing 10 boys over a 15-year period. Sandusky, who maintains his innocence, remains out on $250,000 bail while awaiting trial.

Two Penn State administrators are facing charges they lied to a grand jury investigating Sandusky and failed to properly report suspected child abuse. Gary Schultz, a former vice president, and Tim Curley, the athletic director, have denied the allegations and await trial.

Paterno has described the scandal as one of the great sorrows of his life and has said that in hindsight he wishes he had done more after allegations against Sandusky were raised.

Many alumni are unhappy about the way the school fired Paterno, but some said there were no good options in the situation.

"I don't think there was any graceful way to handle that problem," said John Burness, a former senior vice president of public affairs for Cornell University, Duke University and the University of Illinois.

Harris, who played for Paterno from 1968 to 1971 before helping the Pittsburgh Steelers win four Super Bowls, castigated the Board of Trustees for showing "no courage" by firing the longtime coach. Harris stepped down as chairman of the Pittsburgh Promise, a scholarship foundation, after Mayor Luke Ravenstahl complained about the statements, but he was reinstated in December.

Burness also said that people who are seeking quick changes to the Penn State Board of Trustees forget there's a reason it's difficult to make such changes.

"It isn't a simple thing to do, and it shouldn't be a simple thing to do," he said, since a key goal is for trustees to have a high degree of independence.

___

Begos reported from Pittsburgh.

Also on HuffPost:

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Source: http://www.huffingtonpost.com/2012/01/12/penn-state-scandal-doubts-alumni-rodney-erickson_n_1203099.html

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Thursday, January 12, 2012

Researchers find new, noninvasive way to identify lymph node metastasis

Researchers find new, noninvasive way to identify lymph node metastasis [ Back to EurekAlert! ] Public release date: 12-Jan-2012
[ | E-mail | Share Share ]

Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute

More reliable breast cancer staging could spare sentinel lymph node biopsy and adverse effects

TAMPA, Fla. (Jan. 12, 2012) Using two cell surface markers found to be highly expressed in breast cancer lymph node metastases, researchers at Moffitt Cancer Center, working with colleagues at other institutions, have developed targeted, fluorescent molecular imaging probes that can non-invasively detect breast cancer lymph node metastases. The new procedure could spare breast cancer patients invasive and unreliable sentinel lymph node (SLN) biopsies and surgery-associated negative side effects.

Their study was published in a recent issue of Clinical Cancer Research (18:1), a publication of the American Association for Cancer Research.

"The majority of breast cancer patients, up to 74 percent, who undergo SLN biopsy are found to be negative for axillary nodal, or ALN, metastases," said corresponding author David L. Morse, Ph.D., an associate member at Moffitt whose research areas include experimental therapeutics and diagnostic imaging. "Determining the presence or absence of ALN metastasis is critical to breast cancer staging and prognosis. Because of the unreliability of the SLN biopsy and its potential for adverse effects, a noninvasive, more accurate method to assess lymph node involvement is needed."

The authors note that the postoperative complications to the SLN biopsy can include lymphedema, seroma formation, sensory nerve injury and limitations in patient range of motion. In addition, biopsies fail to identify disease in axillary lymph nodes in five to 10 percent of patients.

In developing targeted molecular probes to identify breast cancer in axillary lymph nodes, the research team from Moffitt, the University of Arizona and University of Florida used two surface cell markers CAIX and CAXII. CAIX is a cell surface marker known to be "highly and broadly expressed in breast cancer lymph node metastases" and absent in normal tissues.

CAIX and CAXII are both integral plasma membrane proteins with large extracellular components that are accessible for binding of targeted imaging probes, explained Morse. In addition, several studies have shown that CAIX expression is associated with negative prognosis and resistance to chemo and radiation therapy for breast cancer. CAXII is a protein expressed in over 75 percent of axillary lymph node metastases.

The researchers subsequently developed their targeting agents by using monoclonal antibodies specific for binding CAIX and CAXII, both of which are known to promote tumor growth.

According to the researchers, a number of noninvasive optical imaging procedures for SLN evaluation have been investigated, but the approaches have lacked the ability to target tumor metastasis biomarkers.

"These methods provide only anatomic maps and do not detect tumor cells present in lymph nodes," explained Morse. "Using mouse models of breast cancer metastasis and a novel, monoclonal anti-body-based molecular imaging agents, we developed a targeted, noninvasive method to detect ALN metastasis using fluorescence imaging."

In addition to the imaging study with mice, the researchers also reported that the combination of CAIX and CAXII covered 100 percent of patient-donated samples used in their tissue microarray (TMA) study.

"The imaging probes detected tumor cells in ALNs with high sensitivity," explained Morse. "Either CAIX or CAXII were expressed in 100 percent of the breast cancer lymph node metasatsis samples we surveyed in this study. These imaging probes have potential for providing a noninvasive way to stage breast cancer in the clinic without unneeded and costly surgery."

###

About Moffitt Cancer Center
Follow Moffitt on Facebook: www.facebook.com/MoffittCancerCenter
Follow Moffitt on Twitter: @MoffittNews
Follow Moffitt on YouTube: MoffittNews

Located in Tampa, Florida, Moffitt Cancer Center is an NCI Comprehensive Cancer Center a designation that recognizes Moffitt's excellence in research and contributions to clinical trials, prevention and cancer control. Moffitt currently has 14 affiliates in Florida, one in Georgia, one in Pennsylvania and two in Puerto Rico. Additionally, Moffitt is a member of the National Comprehensive Cancer Network, a prestigious alliance of the country's leading cancer centers, and is listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer.

Media release by Florida Science Communications


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Researchers find new, noninvasive way to identify lymph node metastasis [ Back to EurekAlert! ] Public release date: 12-Jan-2012
[ | E-mail | Share Share ]

Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute

More reliable breast cancer staging could spare sentinel lymph node biopsy and adverse effects

TAMPA, Fla. (Jan. 12, 2012) Using two cell surface markers found to be highly expressed in breast cancer lymph node metastases, researchers at Moffitt Cancer Center, working with colleagues at other institutions, have developed targeted, fluorescent molecular imaging probes that can non-invasively detect breast cancer lymph node metastases. The new procedure could spare breast cancer patients invasive and unreliable sentinel lymph node (SLN) biopsies and surgery-associated negative side effects.

Their study was published in a recent issue of Clinical Cancer Research (18:1), a publication of the American Association for Cancer Research.

"The majority of breast cancer patients, up to 74 percent, who undergo SLN biopsy are found to be negative for axillary nodal, or ALN, metastases," said corresponding author David L. Morse, Ph.D., an associate member at Moffitt whose research areas include experimental therapeutics and diagnostic imaging. "Determining the presence or absence of ALN metastasis is critical to breast cancer staging and prognosis. Because of the unreliability of the SLN biopsy and its potential for adverse effects, a noninvasive, more accurate method to assess lymph node involvement is needed."

The authors note that the postoperative complications to the SLN biopsy can include lymphedema, seroma formation, sensory nerve injury and limitations in patient range of motion. In addition, biopsies fail to identify disease in axillary lymph nodes in five to 10 percent of patients.

In developing targeted molecular probes to identify breast cancer in axillary lymph nodes, the research team from Moffitt, the University of Arizona and University of Florida used two surface cell markers CAIX and CAXII. CAIX is a cell surface marker known to be "highly and broadly expressed in breast cancer lymph node metastases" and absent in normal tissues.

CAIX and CAXII are both integral plasma membrane proteins with large extracellular components that are accessible for binding of targeted imaging probes, explained Morse. In addition, several studies have shown that CAIX expression is associated with negative prognosis and resistance to chemo and radiation therapy for breast cancer. CAXII is a protein expressed in over 75 percent of axillary lymph node metastases.

The researchers subsequently developed their targeting agents by using monoclonal antibodies specific for binding CAIX and CAXII, both of which are known to promote tumor growth.

According to the researchers, a number of noninvasive optical imaging procedures for SLN evaluation have been investigated, but the approaches have lacked the ability to target tumor metastasis biomarkers.

"These methods provide only anatomic maps and do not detect tumor cells present in lymph nodes," explained Morse. "Using mouse models of breast cancer metastasis and a novel, monoclonal anti-body-based molecular imaging agents, we developed a targeted, noninvasive method to detect ALN metastasis using fluorescence imaging."

In addition to the imaging study with mice, the researchers also reported that the combination of CAIX and CAXII covered 100 percent of patient-donated samples used in their tissue microarray (TMA) study.

"The imaging probes detected tumor cells in ALNs with high sensitivity," explained Morse. "Either CAIX or CAXII were expressed in 100 percent of the breast cancer lymph node metasatsis samples we surveyed in this study. These imaging probes have potential for providing a noninvasive way to stage breast cancer in the clinic without unneeded and costly surgery."

###

About Moffitt Cancer Center
Follow Moffitt on Facebook: www.facebook.com/MoffittCancerCenter
Follow Moffitt on Twitter: @MoffittNews
Follow Moffitt on YouTube: MoffittNews

Located in Tampa, Florida, Moffitt Cancer Center is an NCI Comprehensive Cancer Center a designation that recognizes Moffitt's excellence in research and contributions to clinical trials, prevention and cancer control. Moffitt currently has 14 affiliates in Florida, one in Georgia, one in Pennsylvania and two in Puerto Rico. Additionally, Moffitt is a member of the National Comprehensive Cancer Network, a prestigious alliance of the country's leading cancer centers, and is listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer.

Media release by Florida Science Communications


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/hlmc-rfn011212.php

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Wednesday, January 11, 2012

Oh snap! Bungee jumper plunges into Zambezi River at Victoria Falls (+video)

The Australian survived, but tourists who assume that extreme venues in Africa are safe may be fooling themselves.

Jumping from a bridge down toward a river filled with crocodiles ? what could possibly go wrong?

Skip to next paragraph

A lot, apparently.

On Dec. 31, Australian tourist Erin Langworthy became one of thousands of people to try bungee-jumping off the bridge that connects Zimbabwe and Zambia, within sight of the tourist mecca Victoria Falls. It?s 364 meters of sheer gravitational pleasure, followed by a gut-wrenching jerk just feet above the rapids below. The only problem, for Ms. Langworthy, is that her bungee cord broke and she fell into the Zambezi, which, in its quieter areas, is infested with crocodiles.

?I think it is definitely a miracle that I survived,? Langworthy, an Australian student, told Australia?s Channel Nine in an interview. She says that she lost consciousness on impact, and ?I felt like I?d been slapped all over,? but as she went deeper into the river, the cold water snapped her back into consciousness.

It?s easy to criticize tourists for jumping off bridges. There is, as Disney says, a circle of life.

Bungee-jumping ? a New Zealand innovation in the area of extreme sports ? has been available at this particular spot for more than a decade, and has drawn more than 50,000 tourists each year, providing needed revenue to both the Zimbabwean and Zambian economies. Perhaps fearing that some bad publicity could end the good times, Zambia?s tourism minister, Given Lubinda, assured prospective tourists that the bungee-jumping is, generally speaking, perfectly safe.

?It [the bungee jump] has been in operation for 10 years,? he told the Lusaka Times. ?This is the first time I am hearing of an incident. The probability of an incident is one in 500,000 jumps.?

There is some mathematical truth to this, of course. But as someone who has taken a number of tours in Africa, I would add just a few qualifications.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/8jTvUhZHy9s/Oh-snap!-Bungee-jumper-plunges-into-Zambezi-River-at-Victoria-Falls-video

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Tuesday, January 10, 2012

UK security forces tracked car of alleged IRA man (AP)

DUBLIN ? British anti-terror agents tracked an alleged Irish Republican Army dissident by planting an electronic surveillance device on his car, a prosecutor said Monday at the start of the trial of two men charged with murdering a policeman.

Both men deny fatally shooting Constable Stephen Carroll in a March 2009 ambush claimed by the Continuity IRA splinter group.

Carroll, 48, was the first policeman to be killed in Northern Ireland since 1998, the year of the Good Friday peace accord that sought to end decades of bloodshed over the British territory. While most IRA members disarmed and renounced violence in 2005, small breakaway groups continue to mount sporadic gun and bomb attacks.

The evidence to be presented in coming weeks against alleged IRA dissidents Brendan McConville, 40, and John Wootton, 20, should throw a spotlight on how anti-terror authorities led by the British domestic spy agency MI5 operate in Northern Ireland today.

State prosecutor Ciaran Murphy told Belfast Crown Court that police could connect both defendants to the killing partly because agents planted a GPS tracking device on Wootton's car weeks before the gun attack.

Murphy said agents and detectives would testify that Wootton's car was at the scene of the killing and left it minutes after the officer was shot through the back of the head as he sat in his patrol car in the town of Craigavon.

The policeman's killers lured him to his death by throwing a brick through a window of a family's home and waiting for police to respond. Murphy said Carroll was shot by a Kalashnikov assault rifle from about 50 meters (yards) away.

The attack came two days after another splinter faction, the Real IRA, shot to death two off-duty British soldiers as they collected pizzas from deliverymen at the entrance of an army base in nearby Antrim.

Murphy said police used the GPS data to locate Wootton's car and found inside it a coat belonging to McConville, a former politician from the Irish nationalist Sinn Fein party. He said forensic experts found traces of gunshot residue and Semtex plastic explosive on the jacket.

He said officers found the Kalashnikov hidden under an oil tank outside a Craigavon house.

Libya supplied several tons of Semtex to the IRA in the mid-1980s. Most of the IRA's remaining stock was surrendered to disarmament officials in 2005 but dissidents seized some, too.

IRA dissidents have used Semtex in several attacks since 2008, usually as the core explosive in a larger homemade bomb.

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/ap/20120109/ap_on_re_eu/eu_nireland_policeman_slain

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Two lesbian contestants make history at Miss California USA

Amid the photographs of beauty contestants competing in Miss California USA this weekend are those of two young women who are making history.

Jenelle Hutcherson, 26, of Long Beach and Mollie Thomas, 19, of West Hollywood are the first openly gay contestants in the 60-year history of the state pageant, whose winner will go on to compete in Miss USA, the national pageant.

"That Miss California crown would sure look nice atop the 'hawk," Hutcherson said, referring to her Mohawk hairstyle.

And Thomas wrote Friday on her Facebook fan page, "Interview, check! All-day rehearsal in five-inch heels, ouch! Bring it on."

More than 400 women are vying for the title of Miss California USA and Miss California Teen USA, compared with 378 participants from last year, organizers say.

The state pageant "will emphasize individuality and push the envelope even further," Keith Lewis, co-executive of the contest, said in a statement. "This year's event will be bigger and reflect the progressive attitudes of the contestants."

The history-making journey started Friday and will continue through the weekend at McCallum Theatre in Indian Wells. During the first round on Saturday, contestants will don swimsuits and evening wear. Only 20 women will be selected for the final round on Sunday.

Set apart in age, style and background, both Hutcherson and Thomas were approached by pageant recruiters to participate in the beauty contest.

Thomas, a part-time UCLA student, said this is her first time in a pageant. She agreed to compete because it allowed her to represent the lesbian, gay, bisexual and transgender community in a positive way, she said.

"I'm running for equality and will use this in order to promote visibility on current issues, to become a youth advocate and a role model," Thomas said in an interview.

Thomas has volunteered at a school for handicapped children in Mongolia and at an elephant reservation in northern Thailand and has helped rebuild homes in New Orleans after Hurricane Katrina.

Hutcherson, sporting a pierced nose and tattoos, is also using the contest as part of an effort to spread a message of tolerance and equality. A mentor at the LGBT center in Long Beach, she also hopes to inspire young people.

"We have the power to create a better future for our kids by setting an example of treating each other with love and equality," she said.

This isn't her first time in the spotlight. In October, Hutcherson became the first openly lesbian contestant in the Miss Long Beach pageant, where she made it to the finals.

She wore 1930s-inspired board shorts and a tank top for the swimwear section, and for the evening attire she ditched the gown and heels for a tuxedo. Hutcherson said she planned to change things for the state pageant.

"She's really promoting what she believes in, and it's inspiration to other people," said Miss Long Beach, Kristin Bopp, 23. "I think it's great."

ruben.vives@latimes.com

Source: http://feeds.latimes.com/~r/MostEmailed/~3/4XhVvFIXyDk/la-me-lesbian-beauty-contestant-20120107,0,2358281.story

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Monday, January 9, 2012

Education law's promise falls short after 10 years (AP)

WASHINGTON ? The No Child Left Behind education law was cast as a symbol of possibility, offering the promise of improved schools for the nation's poor and minority children and better prepared students in a competitive world.

Yet after a decade on the books, President George W. Bush's most hyped domestic accomplishment has become a symbol to many of federal overreach and Congress' inability to fix something that's clearly flawed.

The law forced schools to confront the uncomfortable reality that many kids simply weren't learning, but it's primarily known for its emphasis on standardized tests and the labeling of thousands of schools as "failures."

Sunday marks the 10-year anniversary of the day Bush signed it into law in Hamilton, Ohio. By his side were the leaders of the education committees in Congress, Rep. John Boehner, R-Ohio, and Sen. Ted Kennedy, D-Mass. The bipartisanship that made the achievement possible in the months after the Sept. 11 attacks is long gone.

The same Senate committee approved a revamped education bill last year, but deep-rooted partisanship stalled the measure in the full Congress. In this election year, there appears little political will for compromise despite widespread agreement that changes are needed.

Critics say the law carries rigid and unrealistic expectations that put too much of an emphasis on tests for reading and math at the expense of a more well-rounded education.

Frustrated by the congressional inaction, President Barack Obama told states last fall they could seek a waiver around unpopular proficiency requirements in exchange for actions his administration favors. A vast majority of states have said they will go that route, seen as a temporary fix until lawmakers do act.

Like Obama, Republican presidential candidates have criticized the law. One, former Pennsylvania Sen. Rick Santorum, even saying he regrets voting for it.

"If you called a rally to keep No Child Left Behind as it is, not a single person would show up," said Democratic Sen. Michael Bennet of Colorado, Denver's former school superintendent.

The view was drastically different 10 years ago, when Bush took what was an uncommon stance for a conservative in seeking an aggressive federal role in forcing states and districts to tackle abysmal achievement gaps in schools.

He was able to get fellow Republicans such as Boehner, the current House speaker, and Democratic leaders on education such as Kennedy, who died in 2009, and Rep. George Miller, D-Calif., to join him. The mandate was that all students read and perform math on grade level by 2014.

"No longer is it acceptable to hide poor performance. No longer is it acceptable to keep results from parents," Bush said when he signed the legislation. "We're never going to give up on a school that's performing poorly; that when we find poor performance, a school will be given time and incentives and resources to correct their problems."

The law requires annual testing. Districts must keep and publish data showing how subgroups of students perform. Schools that don't meet requirements for two years or longer face increasingly tough consequences, from busing children to higher performing schools to offering tutoring and replacing staff.

The test results were eye-opening, recalled Miller, the top Democrat on the House Education and the Workforce Committee.

"People were stunned because they were always led to believe that things were going fine in this particular school. And the fact of the matter was, for huge numbers of students that was not the case," Miller said. "That led to a lot of anger, disappointment. That led to embarrassment. In many instances, the schools were being held out as exceeding in their mission, when it fact they were failing many, many of the children in those schools."

Under the law, watching movies and assigning irrelevant or no homework was no longer acceptable because suddenly someone was paying attention, said Charles Barone, a former aide to Miller who is director of federal policy with Democrats for Education Reform.

In low-performing urban schools, where teachers and principals once might have thrown up their hands and not known what to do, there was a new attitude along the lines of "we might not know what to do, but we've got to do something," said Eric Hanushek, a senior fellow in education at the Hoover Institution of Stanford University.

Both spoke at a recent forum on the law at the Thomas B. Fordham Institute.

But many teachers

and principals started to believe they were being judged on factors out of their control and in ways that were unfair.

Jennifer Ochoa, an eighth-grade literacy teacher in New York who works with low-performing students, said the law has hurt morale among educators as well as students, who feel they have to do well on a standardized test or are failures, no matter how much progress they make.

"Afterward, it didn't matter how far you came if you didn't make this outside goal," Ochoa said. "We started talking about kids in very different ways. We started talking about kids in statistical ways instead of human being terms."

How successful the law has been academically remains under debate.

Scores on a national assessment show significant gains in math among the fourth- and eighth-graders, with Hispanic and African-American fourth-graders performing approximately two grade levels higher today than when the law was passed, said Mark Schneider, the former U.S. commissioner of education statistics who now serves as vice president at the American Institutes for Research.

"You cannot dismiss these gains, and I think ... people just aren't willing to credit NCLB or accountability in general because of ideological and political preferences," Schneider said.

As the years went by, however, the growth has largely plateaued, Schneider said. Similar large gains were not shown in reading, and some experts say more progress was made in reading before the law was passed. There are still huge differences in the performance of African-American and Hispanic students compared with white students.

As the 2014 deadline draws closer, more schools are failing to meet federal standards, with nearly half not doing so last year, according to the Center on Education Policy. Center officials said that's because some states today have harder tests or have high numbers of immigrant and low-income children, but it's also because the law requires states to raise the bar each year for how many children must pass the test.

Some states had long put off the largest increases to avoid penalties.

In Washington, much of the political debate over the law centers on how much federal control the government should have. Some Republicans want to go so far as to close the Education Department and end federally-imposed annual testing.

Even among Democrats there's been some dissension. The Obama administration, for example, opposed the Senate bill passed in committee under the leadership of Sen. Tom Harkin, D-Iowa, because it said the measure didn't go far enough on accountability; Harkin said it wasn't a perfect bill, but compromise was necessary.

Many educators are now looking to other factors

such as online learning, an increased trend toward teacher evaluations tied to student performance, the federal Race to the Top competition that states have competed in, and the common core standards adopted in the vast majority of states as factors that could provide the next boost in education.

Sen. Lamar Alexander, a former education secretary, said he's hopeful Congress will do what's right and update No Child Left Behind, which became due for renewal in 2007.

"One of the things we ought to be able to do is fix No Child Left Behind," said Alexander, R-Tenn. "What we ought to do is set new realistic goals for it so that schools and schools can have those kinds of goals, and most importantly we need to move out of Washington and back to states and local communities decisions about whether schools and teachers are succeeding or failing."

___

Associated Press writer Dorie Turner in Atlanta contributed to this report.

___

Kimberly Hefling can be followed at http://twitter.com/khefling

___

Online:

Background on the law: http://www2.ed.gov/nclb/landing.jhtml

National Center for Education Statistics: http://nces.ed.gov

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20120107/ap_on_go_ot/us_no_child_left_behind10_years

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President Harry?s Independence day


Published on Saturday 7 January 2012 10:28

ALL hail President Harry!

Sheffield schoolboy Harry Fitzpatrick has launched a revolution ? by declaring independence from the rest of Britain and setting up his very own country.

Instead of being part of the UK, his parents? detached house on Kenwell Drive in Bradway is now the Republic of Libertas ? a tiny nation with its own flag, holidays, parliament, online broadcasting service and postal system.

Harry, aged 12, is the country?s self-styled head of state ? His Excellency President Fitzpatrick of Libertas.

The country has just six citizens ? his mum Jill, 39, dad Martin, 43, younger brothers Max and Frankie, and grandmother Sandra Pass, 67, who runs a small ?enclave? from her apartment in Hillsborough.

Notable landmarks in Libertas include Secession Square ? the Fitzpatricks? garden ? along with a cafe, which looks remarkably similar to the family?s kitchen.

The nation?s official conference hall is better known as the dining room.

Harry said his friends think he is ?a bit bonkers? while his parents also view his presidential ambitions as being slightly eccentric.

But he added: ?It?s a very fun thing to do. I?d certainly like more people to get involved in running their own countries.?

Of course, Libertas isn?t officially a country.

The ?micronation? is part of a movement which has gained popularity on the internet. Harry said he was inspired by reading about Sealand, an unrecognised country set up by Army Major Paddy Roy Bates on a WWII fort off the coast of Suffolk in 1967. Harry said declaring independence had been quite enjoyable. ?I started up a YouTube channel and sent a message to the UK government,? he said. ?I didn?t hear anything so we just assumed all was well. I don?t think they mind .?

Harry said most of the ?day-to-day admin? is carried out at the ?presidential palace? ? his bedroom ? but he does find time to attend classes as a Year 7 pupil at Meadowhead School.

Life in the Republic of Libertas consists mainly of ?watching movies with each other, dining out at restaurants, and having a bit of a laugh?, says Harry.

The national dish is the fajita, while the laws of the land decree tobacco, swearing, alcoholic disorder and illegal drugs are all banned.


Source: http://www.thestar.co.uk/president_harry_s_independence_day_1_4118111

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Friday, January 6, 2012

Nintendo sold four million 3DS consoles, 4.5 million Wiis in US last year

We've been (somewhat) taken with Nintendo's dual-screen handheld's 3D screen, AR features and overall unique experience, but it appears that the 3DS has been a real boon to gamers, with more than four million U.S. consumers picking up the console since it hit stores in March of last year. 3DS games like Super Mario 3D Land and Mario Kart 7, which sold more than one million units each in the US alone, were also incredibly popular, along with the aging Wii, which made its way to 4.5 million additional U.S. households in 2011. All told, Nintendo sold more than 12 million consoles stateside last year, and has solid hopes for an equally successful 2012. As always, you can get your fill of warm and fuzzy PR magic just past the break.

Continue reading Nintendo sold four million 3DS consoles, 4.5 million Wiis in US last year

Nintendo sold four million 3DS consoles, 4.5 million Wiis in US last year originally appeared on Engadget on Tue, 03 Jan 2012 09:26:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/01/03/nintendo-sells-four-million-3ds-consoles-4-5-million-wiis-in-us/

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Wednesday, January 4, 2012

Iowa caucus: Why Mitt Romney can't lose

Mitt Romney is leading in some polls ahead of the Iowa caucus. But even if Romney finishes second to Ron Paul or Rick Santorum in Iowa, he'll still come out ahead, says DCDecoder.

So at last it?s come - the moment we?ve all been waiting for. Tonight in Iowa, rank-and-file voters will finally have a say, making their picks for the Republican nominee for president.

Skip to next paragraph

We confess, election days often seem exciting and anticlimactic at the same time, and today is no different. For one thing, the Iowa caucuses won?t actually get underway until? 8 pm East Coast time tonight - meaning we still have a few more hours of breathless nonstop media coverage before anything actually happens.

And this year, that feeling of anticlimax is even stronger than usual, because, for all the media hoopla about Rick Santorum?s surge in Iowa - and make no mistake, it is a real surge - we?re still pretty sure Mitt Romney?s got this ?thing? (as he put it yesterday) in the bag.

Romney may not win Iowa outright - though the latest polls show he?s currently in the best position to do so of any of the candidates. But even if he loses Iowa to Santorum or Ron Paul, we just don?t see any conceivable way Romney?s going to lose the nomination in the long run.

Consider: Santorum has almost nothing in the way of money or organization. True, if he wins Iowa, he will get the famed ?bump.? But what will that bring? A ton of media scrutiny and attacks from other candidates. Remember, New Hampshire doesn?t vote until January 10 - and these days, a week is a lifetime in politics. Santorum has a long record of votes to pick over, and the media has only begun to examine his more controversial statements (like seeming to equate homosexuality with bestiality - which led to his well-known??Google problem?) and actions (like bringing the dead body of his prematurely born child home from the hospital and allowing his other children to hold it).

Unlike Santorum, Ron Paul does have an organization. But we?ve said it before and we?ll say it again: There is simply no way Paul will ever win the Republican nomination. Yes, he appeals to many conservatives on fiscal matters, with his vow to slash government spending, cut agencies, etc. But his views on foreign affairs - he is opposed to nearly all foreign intervention and says he would not have approved the operation that killed Osama bin Laden, or the drone attacks that have killed other Al Qaeda leaders - make him flat-out unelectable within the GOP.

Meanwhile, the only candidates who ever might have had a real shot at building the kind of top-tier mainstream campaign that could actually challenge Romney - Newt Gingrich and Rick Perry - have sunk like stones. They do have some money (Gingrich said he raised $9 million in the 4th quarter) and it?s possible they could still make things interesting. But assuming they finish fourth or worse tonight (as polls suggest they will), it?s hard to see how they actually get back into contention.

This doesn?t mean we necessarily think all the fun is over. Romney will likely encounter at least a few more bumps in the road on the way to the nomination. If he comes in third tonight, or even a weak second, that will induce lots of hand-wringing about whether he has a ?ceiling? of support that simply can?t be cracked. But ultimately, it won?t matter: barring something extraordinary and unexpected, Mitt Romney will be the Republican nominee. The only question is how long it takes.

Like your politics unscrambled? Check out DCDecoder.com

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/ubM2p-Vrw0c/Iowa-caucus-Why-Mitt-Romney-can-t-lose

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Barry Hearn is ready to crack the darts market in China

By Richard Lewis

BARRY HEARN is ready to crack the darts market in China as the sport?s global expansion gathers pace.

Hearn, chairman of the PDC, is set to stage events in Beijing after a Ladbrokes World Championship at Alexandra Palace which saw the event shown live in Australia, New Zealand, the Middle East, Holland and Germany, along with USA delayed coverage.

?You look at the golf circuit. And you can ask ?Why aren?t we playing in Beijing? Well, we will be,? said Hearn. ?It is reaching a global audience and the crowds here have been amazing.? Over 50,000 people have attended, with the final tonight.

?I spend a lot of time thinking, ?When is the bubble going to burst??? said Hearn. ?I hate complacency and I am constantly asking our customers, ?What else do you need?? and ?How do we make it a better experience???


Source: http://uk.express.feedsportal.com/c/33338/f/565874/s/1b702d2a/l/0L0Sdailyexpress0O0Cposts0Cview0C2930A80A0CReal0EChinese0Ecracker0C/story01.htm

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Sunday, January 1, 2012

Gingrich Weeps at Des Moines Town Hall (Little green footballs)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/181137578?client_source=feed&format=rss

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Letter airs harassment claims against HP's ex-CEO

(AP) ? Former Hewlett-Packard CEO Mark Hurd's efforts to impress an HP event hostess included showing her his checking-account balance holding over $1 million, according to a letter detailing the sexual harassment allegations that led to his ouster.

The letter was obtained late Thursday by The Associated Press after the Delaware Supreme Court ruled that Hurd's lawyers, who had attempted to keep it confidential, didn't show that disclosing it would violate California privacy rights. The ruling said information that is only "mildly embarrassing" is not protected from public disclosure.

The letter, it added, does not contain trade secrets about the Palo Alto-based technology company or non-public financial information. Some sentences concerning Hurd's family were ordered redacted.

Celebrity attorney Gloria Allred sent the letter last year on behalf of Jodie Fisher, who was hired as a contract employee to help with HP networking events and who later accused Hurd of sexual harassment.

Although an HP investigation did not find any evidence to support the harassment claim, it uncovered inaccurate expense reports for his outings with Fisher. Hurd was ultimately forced out in August 2010. He now works as co-president at rival Oracle Corp.

Allred alleged in the letter that, while Fisher was ostensibly hired an HP event hostess in late 2007, she was really brought on to accompany Hurd to HP events held out of town. Throughout 2008 and 2009, Hurd made it clear he expected to have a sexual relationship with Fisher, using his "status and authority as CEO of HP," Allred alleged.

Allred claimed that Hurd made several sexual advances toward Fisher, which Fisher rejected. In 2008, while walking with Fisher in Madrid, Hurd stopped at an ATM and showed her his checking-account balance "to impress her," according to the letter.

After Fisher rejected him a final time in October 2009, she was not hired for any future HP events, Allred alleged.

Allred also alleged that in March 2008, Hurd told Fisher that HP was likely to purchase technology services vendor EDS. HP announced the $13 billion acquisition in May of that year.

HP shareholder Ernesto Espinoza had sued to have the letter unsealed. Hurd's attorney, Amy Wintersheimer, said his lawyers had requested that the letter be kept confidential because "it is filled with inaccuracies."

"The truth is, there never was any sexual harassment, which HP's investigation confirmed, and there never was any sexual relationship, which Ms. Fisher has confirmed," Wintersheimer said in a statement.

Both Allred and Hewlett-Packard Co. had no comment on the letter's contents.

___

Ortutay reported from New York.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2011-12-30-US-TEC-Mark-Hurd-Letter/id-9082e74489da4ca5857ee4fd726cab12

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